IUBMB Enzyme Nomenclature

EC 1.14.13.102

Accepted name: psoralen synthase

Reaction: (+)-marmesin + NADPH + H+ + O2 = psoralen + NADP+ + acetone + 2 H2O

For diagram of reaction click here.

Glossary: (+)-marmesin = (S)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one
psoralen = 7H-furo[3,2-g]chromen-7-one

Other name(s): CYP71AJ1

Systematic name: (+)-marmesin,NADPH:oxygen oxidoreductase

Comments: This microsomal cytochrome P450-dependent enzyme is specific for (+)-marmesin, and to a much lesser extent 5-hydroxymarmesin, as substrate. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, is not a substrate for the enzyme but it is a competitive inhibitor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Larbat, R., Kellner, S., Specker, S., Hehn, A., Gontier, E., Hans, J., Bourgaud, F. and Matern, U. Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. J. Biol. Chem. 282 (2007) 542-554. [PMID: 17068340]

[EC 1.14.13.102 created 2007]


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