IUBMB Enzyme Nomenclature


Accepted name: 11β-hydroxysteroid dehydrogenase

Reaction: an 11β-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+

Other name(s): corticosteroid 11β-dehydrogenase; β-hydroxysteroid dehydrogenase; 11β-hydroxy steroid dehydrogenase; corticosteroid 11-reductase; dehydrogenase, 11β-hydroxy steroid

Systematic name: 11β-hydroxysteroid:NADP+ 11-oxidoreductase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9041-46-7


1. Agarwal, A.K., Monder, C., Eckstein, B. and White, P.C. Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. J. Biol. Chem. 264 (1989) 18939-18943. [PMID: 2808402]

2. Bush, I.E., Hunter, S.A. and Meigs, R.A. Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver. Biochem. J. 107 (1968) 239-258. [PMID: 4384445]

3. Lakshmi, V. and Monder, C. Purification and characterization of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology 123 (1988) 2390-2398. [PMID: 3139396]

4. Phillips, D.M., Lakshmi, V. and Monder, C. Corticosteroid 11β-dehydrogenase in rat testis. Endocrinology 125 (1989) 209-216. [PMID: 2661206]

[EC created 1972]

Return to EC 1.1.1 home page
Return to EC 1.1 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page