IUBMB Enzyme Nomenclature


Accepted name: 21-hydroxysteroid dehydrogenase (NAD+)

Reaction: pregnan-21-ol + NAD+ = pregnan-21-al + NADH + H+

Systematic name: 21-hydroxysteroid:NAD+ 21-oxidoreductase

Other name(s): 21-hydroxysteroid dehydrogenase (NAD)

Comments: Acts on a number of 21-hydroxycorticosteroids.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 37250-75-2


1. Monder, C. and White, A. The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases. J. Biol. Chem. 240 (1965) 71-77.

[EC created 1972]

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