IUBMB Enzyme Nomenclature


Accepted name: 7α-hydroxysteroid dehydrogenase

Reaction: cholate + NAD+ = 3α,12α-dihydroxy-7-oxo-5β-cholanate + NADH + H+

Glossary: cholate = 3α,7α,12α-trihydroxy-5β-cholanate

Other name(s): 7α-hydroxy steroid dehydrogenase; 7α-HSDH

Systematic name: 7α-hydroxysteroid:NAD+ 7-oxidoreductase

Comments: Catalyses the oxidation of the 7α-hydroxyl group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 39361-64-3


1. Haslewood, E.S. and Haslewood, G.A.D. The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli. Biochem. J. 157 (1976) 207-210. [PMID: 786279]

2. Macdonald, I.A. and Roach, P.D. Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum. Biochim. Biophys. Acta 665 (1981) 262-269. [PMID: 6945134]

3. Macdonald, I.A., Williams, C.N. and Mahony, D.E. 7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies. Biochim. Biophys. Acta 309 (1973) 243-253. [PMID: 4581498

4. Macdonald, I.A., Williams, C.N., Mahony, D.E. and Christie, W.M. NAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis. Biochim. Biophys. Acta 384 (1975) 12-24. [PMID: 236764]

[EC created 1976, modified 1980]

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