IUBMB Enzyme Nomenclature


Accepted name: hydroxycyclohexanecarboxylate dehydrogenase

Reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H+

Other name(s): dihydroxycyclohexanecarboxylate dehydrogenase; (–)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase

Systematic name: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase

Comments: Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (–)-quinate and (–)-shikimate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 55467-53-3


1. Whiting, G.C. and Coggins, R.A. A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (–)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate. Biochem. J. 141 (1974) 35-42. [PMID: 4375976]

[EC created 1976]

Return to EC 1.1.1 home page
Return to EC 1.1 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page