IUBMB Enzyme Nomenclature


Accepted name: mannitol-1-phosphate 5-dehydrogenase

Reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+

Other name(s): hexose reductase; mannitol 1-phosphate dehydrogenase; D-mannitol-1-phosphate dehydrogenase; fructose 6-phosphate reductase

Systematic name: D-mannitol-1-phosphate:NAD+ 5-oxidoreductase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9028-24-4


1. Marmur, J. and Hotchkiss, R.D. Mannitol metabolism, a transferable property of pneumococcus. J. Biol. Chem. 214 (1955) 383-396.

2. Wolfe, J.B. and Kaplan, N.O. Hexose phosphate and hexose reductase. A. D-Mannitol-1-phosphate dehydrogenase from E. coli. Methods Enzymol. 1 (1955) 346-348.

3. Wolfe, J.B. and Kaplan, N.O. D-Mannitol 1-phosphate dehydrogenase from Escherichia coli. J. Biol. Chem. 218 (1956) 849-869.

[EC created 1961]

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