Reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+
For diagram click here.
Other name(s): GDP-4-keto-6-deoxy-D-mannose reductase; GDP-4-keto-D-rhamnose reductase; guanosine diphosphate-4-keto-D-rhamnose reductase
Systematic name: GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase
Comments: In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 9075-56-3
References:
1. Barber, G.A. The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant. Biochim. Biophys. Acta 165 (1968) 68-75. [PMID: 4386238]
2. Winkler, N.W. and Markovitz, A. Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme. J. Biol. Chem. 246 (1971) 5868-5876. [PMID: 4398966]