IUBMB Enzyme Nomenclature


Accepted name: 15-hydroxyprostaglandin dehydrogenase (NADP+)

Reaction: (13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11α-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+

Other name(s): NADP-dependent 15-hydroxyprostaglandin dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; type II 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP)

Systematic name: (13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

Comments: Acts on prostaglandins E2, F2α and B1, but not on prostaglandin D2 [cf. EC 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC prostaglandin-E2 9-reductase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 54989-39-8


1. Lee, S.-C. and Levine, L. Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types. J. Biol. Chem. 250 (1975) 548-552. [PMID: 234431]

2. Lee, S.-C., Pong, S.-S., Katzen, D., Wu, K.-Y. and Levine, L. Distribution of prostaglandin E 9-ketoreductase and types I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex. Biochemistry 14 (1975) 142-145. [PMID: 803247]

[EC created 1984]

Return to EC 1.1.1 home page
Return to EC 1.1 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page