IUBMB Enzyme Nomenclature

EC 1.1.1.201

Accepted name: 7β-hydroxysteroid dehydrogenase (NADP+)

Reaction: A 7β-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+

Other name(s): NADP-dependent 7β-hydroxysteroid dehydrogenase; 7β-hydroxysteroid dehydrogenase (NADP)

Systematic name: 7β-hydroxysteroid:NADP+ 7-oxidoreductase

Comments: Catalyses the oxidation of the 7β-hydroxy group of bile acids such as ursodeoxycholate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 79393-83-2

References:

1. Hirano, S. and Masuda, N. Characterization of NADP-dependent 7β-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens. Appl. Environ. Microbiol. 43 (1982) 1057-1063. [PMID: 6954878]

2. Macdonald, I.A. and Roach, P.D. Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum. Biochim. Biophys. Acta 665 (1981) 262-269. [PMID: 6945134]

3. Macdonald, I.A., Rochon, Y.P., Hutchison, D.M. and Holdeman, L.V. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7β-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7α-hydroxysteroid dehydrogenase-elaborating organisms. Appl. Environ. Microbiol. 44 (1982) 1187-1195. [PMID: 6758698]

[EC 1.1.1.201 created 1984]


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