Reaction: 5α-androstan-3β,17β-diol + NADP+ = 17β-hydroxy-5α-androstan-3-one + NADPH + H+
Other name(s): progesterone reductase; dehydrogenase, 3β,20α-hydroxy steroid; 3β,20α-hydroxysteroid oxidoreductase
Systematic name: 3β(or 20α)-hydroxysteroid:NADP+ oxidoreductase
Comments: Also acts on 20α-hydroxysteroids.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 82869-26-9
1. Sharaf, M.A. and Sweet, F. Dual activity at an enzyme active site: 3β,20α-hydroxysteroid oxidoreductase from fetal blood. Biochemistry 21 (1982) 4615-4620. [PMID: 6958329]