Reaction: a 3α-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+
Other name(s): 3α-hydroxysteroid dehydrogenase; AKR1C2 (gene name); Akr1c9 (gene name); 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific); 3α-hydroxysteroid 3-dehydrogenase (A-specific)
Systematic name: 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)
Comments: The enzyme acts on multiple 3α-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC 18.104.22.168, 3α-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC 22.214.171.1247, 3α-hydroxysteroid 3-dehydrogenase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-56-2
1. Björkhem, I. and Danielsson, H. Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by Δ4-3-oxosteroid 5-β-reductase and 3-α-hydroxysteroid dehydrogenase from rat liver. Eur. J. Biochem. 12 (1970) 80-84. [PMID: 4392180]
2. Tomkins, G.M. A mammalian 3α-hydroxysteroid dehydrogenase. J. Biol. Chem. 218 (1956) 437-447. [PMID: 13278351]