Reaction: a 3α-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+
Other name(s): 3α-hydroxysteroid dehydrogenase; AKR1C2 (gene name); Akr1c9 (gene name)
Systematic name: 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific)
Comments: The enzyme acts on multiple 3α-hydroxysteroids. A-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3α-hydroxysteroid 3-dehydrogenase (B-specific)].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-56-2
References:
1. Björkhem, I. and Danielsson, H. Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by Δ4-3-oxosteroid 5-β-reductase and 3-α-hydroxysteroid dehydrogenase from rat liver. Eur. J. Biochem. 12 (1970) 80-84. [PMID: 4392180]
2. Tomkins, G.M. A mammalian 3α-hydroxysteroid dehydrogenase. J. Biol. Chem. 218 (1956) 437-447. [PMID: 13278351]
3. Dufort, I., Soucy, P., Labrie, F. and Luu-The, V. Molecular cloning of human type 3 3α-hydroxysteroid dehydrogenase that differs from 20α-hydroxysteroid dehydrogenase by seven amino acids. Biochem. Biophys. Res. Commun. 228 (1996) 474-479. [PMID: 8920937]
4. Nahoum, V., Gangloff, A., Legrand, P., Zhu, D.W., Cantin, L., Zhorov, B.S., Luu-The, V., Labrie, F., Breton, R. and Lin, S.X. Structure of the human 3α-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-Å resolution. J. Biol. Chem. 276 (2001) 42091-42098. [PMID: 11514561]