IUBMB Enzyme Nomenclature


Accepted name: 3α-hydroxysteroid 3-dehydrogenase (Re-specific)

Reaction: a 3α-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+

Other name(s): 3α-hydroxysteroid dehydrogenase; AKR1C2 (gene name); Akr1c9 (gene name); 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific); 3α-hydroxysteroid 3-dehydrogenase (A-specific)

Systematic name: 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)

Comments: The enzyme acts on multiple 3α-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC, 3α-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC, 3α-hydroxysteroid 3-dehydrogenase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-56-2


1. Björkhem, I. and Danielsson, H. Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by Δ4-3-oxosteroid 5-β-reductase and 3-α-hydroxysteroid dehydrogenase from rat liver. Eur. J. Biochem. 12 (1970) 80-84. [PMID: 4392180]

2. Tomkins, G.M. A mammalian 3α-hydroxysteroid dehydrogenase. J. Biol. Chem. 218 (1956) 437-447. [PMID: 13278351]

[EC created 1986, modified 2012, modified 2013]

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