IUBMB Enzyme Nomenclature


Accepted name: diethyl 2-methyl-3-oxosuccinate reductase

Reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + NADPH + H+

Systematic name: diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase

Comments: Also acts on diethyl (2S,3R)-2-methyl-3-hydroxysuccinate; and on the corresponding dimethyl esters.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 110369-21-6


1. Furuichi, A., Akita, H., Matsukura, H., Oishi, T. and Horikoshi, K. Purification and properties of an asymmetric reduction of diethyl 2-methyl-3-oxosuccinate in Saccharomyces fermentati. Agric. Biol. Chem. 51 (1987) 293-299.

[EC created 1990]

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