IUBMB Enzyme Nomenclature


Accepted name: 12β-hydroxysteroid dehydrogenase

Reaction: 3α,7α,12β-trihydroxy-5β-cholan-24-oate + NADP+ = 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate + NADPH + H+

Other name(s): 12β-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase

Systematic name: 12β-hydroxysteroid:NADP+ 12-oxidoreductase

Comments: Acts on a number of bile acids, both in their free and conjugated forms.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 118390-62-8


1. Edenharder, R. and Pfützner, A. Characterization of NADP-dependent 12β-hydroxysteroid dehydrogenase from Clostridium paraputrificum. Biochim. Biophys. Acta 962 (1988) 362-370. [PMID: 3167086]

[EC created 1992]

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