Reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
Other name(s): 3α,17β-hydroxy steroid dehydrogenase; 3α(17β)-HSD; 3α(17β)-hydroxysteroid dehydrogenase (NAD)
Systematic name: 3α(or 17β)-hydroxysteroid:NAD+ oxidoreductase
Comments: Also acts on other 17β-hydroxysteroids, on the 3α-hydroxy group of pregnanes and bile acids, and on benzene dihydrodiol. Different from EC 1.1.1.50 3α-hydroxysteroid dehydrogenase (B-specific) or EC 1.1.1.213 3α-hydroxysteroid dehydrogenase (A-specific).
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 126469-82-7
References:
1. Ohmura, M., Hara, A., Nakagawa, M. and Sawada, H. Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver. Biochem. J. 266 (1990) 583-589. [PMID: 2317205]