Reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+
For reaction pathway click here.
Other name(s): dTDP-4-keto-6-deoxyglucose reductase
Systematic name: dTDP-D-fucose:NADP+ oxidoreductase
Comments: The enzyme from the Gram-negative bacterium Actinobacillus actinomycetemcomitans forms activated fucose for incorporation into capsular polysaccharide.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number:
Reference:
1. Yoshida, Y., Nakano, Y., Nezu, T., Yamashita, Y. and Koga, T. A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose. J. Biol. Chem. 274 (1999) 16933-16939. [PMID: 10358040]