Reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
Other name(s): 2,5-diketo-D-gluconate reductase (ambiguous)
Systematic name: 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase (2-dehydro-D-gluconate-forming)
Comments: The enzyme is involved in the catabolism of 2,5-didehydrogluconate. cf. EC 220.127.116.116, 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 95725-95-4
1. Sonoyama, T., Kageyama, B., Yagi, S. and Mitsushima, K. Biochemical aspects of 2-keto-L-gulonate accumulation from 2,5-diketo-D-gluconate by Corynebacterium sp. and its mutants. Agric Biol Chem. 51 (1987) 3039-3047.