IUBMB Enzyme Nomenclature

EC 1.1.1.282

Accepted name: quinate/shikimate dehydrogenase

Reaction: (1) L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+

(2) shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+

For diagram, click here.

Glossary: quinate = a cyclitol carboxylate

The numbering system used for the 3-dehydroquinate is that of the recommendations on cyclitols, sections I-8 and I-9: and is shown in the reaction diagram. The use of the term '5-dehydroquinate' for this compound is based on an earlier system of numbering.

Other name(s): YdiB

Systematic name: L-quinate:NAD(P)+ 3-oxidoreductase

Comments: This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, shikimate dehydrogenase, in that it can use both quinate and shikimate as substrate and either NAD+ or NADP+ as acceptor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:

References:

1. Michel, G., Roszak, A.W., Sauvé, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. Structures of shikimate dehydrogenase AroE and its paralog YdiB. A common structural framework for different activities. J. Biol. Chem. 278 (2003) 19463-19472. [PMID: 12637497]

2. Benach, J., Lee, I., Edstrom, W., Kuzin, A.P., Chiang, Y., Acton, T.B., Montelione, G.T. and Hunt, J.F. The 2.3-Å crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase. J. Biol. Chem. 278 (2003) 19176-19182. [PMID: 12624088]

[EC 1.1.1.282 created 2004]


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