Reaction: (1) D-arabinitol + NADP+ = D-xylulose + NADPH + H+
(2) D-arabinitol + NADP+ = D-ribulose + NADPH + H+
Other name(s): NADP+-dependent D-arabitol dehydrogenase; ARD1p; D-arabitol dehydrogenase 1
Systematic name: D-arabinitol:NADP+ oxidoreductase
Comments: The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 188.8.131.52, D-arabinitol 4-dehydrogenase and EC 184.108.40.206, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Link, T., Lohaus, G., Heiser, I., Mendgen, K., Hahn, M. and Voegele, R.T. Characterization of a novel NADP+-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae. Biochem. J. 389 (2005) 289-295. [PMID: 15796718]