Reaction: estradiol-17β + NAD(P)+ = estrone + NAD(P)H + H+
Other name(s): 20α-hydroxysteroid dehydrogenase; 17β,20α-hydroxysteroid dehydrogenase; 17β-estradiol dehydrogenase; estradiol dehydrogenase; estrogen 17-oxidoreductase; 17β-HSD
Systematic name: estradiol-17β:NAD(P)+ 17-oxidoreductase
Comments: Also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group. B-specific with respect to NAD(P)+ (cf. EC 1.1.1.149 20α-hydroxysteroid dehydrogenase).
Links to other databases: BRENDA, EXPASY, GTD, KEGG, PDB, CAS registry number: 9028-61-9
References:
1. Kautsky, M.P. and Hagerman, D.D. 17β-Estradiol dehydrogenase of ovine ovaries J. Biol. Chem. 245 (1970) 1978-1984. [PMID: 4314937]
2. Langer, L.J., Alexander, J.A. and Engel, L.L. Human placental estradiol-17β dehydrogenase. II. Kinetics and substrate specificities. J. Biol. Chem. 234 (1959) 2609-2614.