Reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
Other name(s): 17-ketoreductase; 17β-HSD
Systematic name: 17β-hydroxysteroid:NAD+ 17-oxidoreductase
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 9028-62-0
References:
1. Endahl, G.L., Kochakia, C.D. and Hamm, D. Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 2792-2796.
2. Sweat, M.L., Samuels, L.T. and Lumry, R. Preparation and characterisation of the enzyme which converts testosterone to androstendione. J. Biol. Chem. 185 (1950) 75-84.
3. Villee, C.A. and Spencer, J.M. Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 3615-3619.