IUBMB Enzyme Nomenclature


Accepted name: testosterone 17β-dehydrogenase (NADP+)

Reaction: testosterone + NADP+ = androstenedione + NADPH + H+

Glossary: androstenedione = androst-4-ene-3,17-dione

Other name(s): 17-ketoreductase; NADP-dependent testosterone-17β-oxidoreductase; testosterone 17β-dehydrogenase (NADP)

Systematic name: 17β-hydroxysteroid:NADP+ 17-oxidoreductase

Comments: Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-63-1


1. Endahl, G.L., Kochakia, C.D. and Hamm, D. Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 2792-2796.

2. Sweat, M.L., Samuels, L.T. and Lumry, R. Preparation and characterisation of the enzyme which converts testosterone to androstendione. J. Biol. Chem. 185 (1950) 75-84.

3. Villee, C.A. and Spencer, J.M. Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 3615-3619.

[EC created 1965]

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