Reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+
Other name(s): methylglyoxal reductase; D-lactaldehyde dehydrogenase
Systematic name: (R)-lactaldehyde:NAD+ oxidoreductase
Comments: This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH-dependent), in using NADH rather than NADPH as reductant. It oxidizes HO-CH2-CHOH-CHO (glyceraldehyde) as well as CH3-CHOH-CHO (lactaldehyde).
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 37250-16-1
References:
1. Ting, S.-M., Miller, O.N. and Sellinger, O.Z. The metabolism of lactaldehyde. VII. The oxidation of D-lactaldehyde in rat liver. Biochim. Biophys. Acta 97 (1965) 407-415. [PMID: 14323585]