Reaction: glycolate + NADP+ = glyoxylate + NADPH + H+
Other name(s): NADPH-glyoxylate reductase; glyoxylate reductase (NADP); glyoxylate reductase (NADP)
Systematic name: glycolate:NADP+ oxidoreductase
Comments: Also reduces hydroxypyruvate to glycerate; has some affinity for NAD+.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 37250-17-2
1. Cartwright, L.N. and Hullin, R.P. Purification and properties of two glyoxylate reductases from a species of Pseudomonas. Biochem. J. 101 (1966) 781-791.
2. Kleczkowski, L.A., Randall, D.D. and Blevins, D.G. Purification and characterization of a novel NADPH(NADH)-dependent glyoxylate reductase from spinach leaves. Comparison of immunological properties of leaf glyoxylate reductase and hydroxypyruvate reductase. Biochem. J. 239 (1986) 653-659. [PMID: 3548703]