IUBMB Enzyme Nomenclature


Accepted name: malate dehydrogenase (NADP+)

Reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+

Other name(s): NADP-malic enzyme; NADP-malate dehydrogenase; malic dehydrogenase (nicotinamide adenine dinucleotide phosphate); malate NADP dehydrogenase; NADP malate dehydrogenase; NADP-linked malate dehydrogenase; malate dehydrogenase (NADP)

Systematic name: (S)-malate:NADP+ oxidoreductase

Comments: Activated by light.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37250-19-4


1. Connelly, J.L., Danner, D.J. and Bowden, J.A. Branched chain α-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver α-ketoisocaproic:α-keto-β-methylvaleric acid dehydrogenase. J. Biol. Chem. 243 (1968) 1198-1203. [PMID: 5689906]

2. Johnson, H.S. NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis. Biochem. Biophys. Res. Commun. 43 (1971) 703-709. [PMID: 4397919]

3. Johnson, H.S. and Hatch, M.D. Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis. Biochem. J. 119 (1970) 273-280. [PMID: 4395182]

[EC created 1972]

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