Reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH
For diagram of reaction click here.
Other name(s): β,β-dimethylmalate dehydrogenase
Systematic name: (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)
Comments: Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-21-8
1. Magee, P.T. and Snell, E.E. The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to α-ketoisovalerate. Biochemistry 5 (1966) 409-416. [PMID: 4287371]