IUBMB Enzyme Nomenclature


Accepted name: dimethylmalate dehydrogenase

Reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH

For diagram of reaction click here.

Other name(s): β,β-dimethylmalate dehydrogenase

Systematic name: (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)

Comments: Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-21-8


1. Magee, P.T. and Snell, E.E. The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to α-ketoisovalerate. Biochemistry 5 (1966) 409-416. [PMID: 4287371]

[EC created 1972]

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