IUBMB Enzyme Nomenclature


Accepted name: homoisocitrate dehydrogenase

Reaction: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+

For diagram click here.

Glossary: homoisocitrate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

Other name(s): 2-hydroxy-3-carboxyadipate dehydrogenase; 3-carboxy-2-hydroxyadipate dehydrogenase; homoisocitric dehydrogenase; (–)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating); 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating); HICDH

Systematic name: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)

Comments: Forms part of the lysine biosynthesis pathway in fungi [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9067-90-7


1. Strassman, M. and Ceci, L.N. Enzymatic formation of a-ketoadipic acid from homoisocitric acid. J. Biol. Chem. 240 (1965) 4357-4361. [PMID: 4284830]

2. Rowley, B. and Tucci, A.F. Homoisocitric dehydrogenase from yeast. Arch. Biochem. Biophys. 141 (1970) 499-510. [PMID: 4395693]

3. Zabriskie, T.M. and Jackson, M.D. Lysine biosynthesis and metabolism in fungi. Nat. Prod. Rep. 17 (2000) 85-97. [PMID: 10714900]

[EC created 1972 (EC created 1976, incorporated 2004)]

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