Reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
For diagram click here.
Other name(s): β-hydroxy-β-methylglutaryl coenzyme A reductase; β-hydroxy-β-methylglutaryl CoA-reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl coenzyme A reductase
Systematic name: (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37250-24-1
1. Fimognari, G.M. and Rodwell, V.W. Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). Biochemistry 4 (1965) 2086-2090.