IUBMB Enzyme Nomenclature


Accepted name: diiodophenylpyruvate reductase

Reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+

Other name(s): aromatic α-keto acid; KAR; 2-oxo acid reductase

Systematic name: 3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase

Comments: Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 37250-31-0


1. Zannoni, V.G. and Weber, W.W. Isolation and properties of aromatic α-keto acid reductase. J. Biol. Chem. 241 (1966) 1340-1344. [PMID: 5935348]

[EC created 1972]

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