Reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+
Other name(s): lactic acid dehydrogenase; cytochrome b2 (flavin-free derivative of flavocytochrome b2); flavocytochrome b2; L-lactate cytochrome c reductase; L(+)-lactate:cytochrome c oxidoreductase; dehydrogenase, lactate (cytochrome); L-lactate cytochrome c oxidoreductase; lactate dehydrogenase (cytochrome); lactic cytochrome c reductase
Systematic name: (S)-lactate:ferricytochrome-c 2-oxidoreductase
Comments: Identical with cytochrome b2; a flavohemoprotein (FMN).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9078-32-4
1. Appleby, C.A. and Morton, R.K. Lactic dehydrogenase and cytochrome b2 of baker's yeast. Purification and crystallization. Biochem. J. 71 (1959) 492-499. [PMID: 13638255]
2. Appleby, C.A. and Morton, R.K. Lactic dehydrogenase and cytochrome b2 of baker's yeast. Enzymic and chemical properties of the crystalline enzyme. Biochem. J. 73 (1959) 539-550. [PMID: 13793977]
3. Bach, S.G., Dixon, M. and Zerfas, L.G. Yeast lactic dehydrogenase and cytochrome b2. Biochem. J. 40 (1946) 229-239. [PMID: 16747991]
4. Nygaard, A.P. Lactate dehydrogenases of yeast. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol.7, Academic Press, New York, 1963, p. 557-565.