IUBMB Enzyme Nomenclature


Accepted name: malate dehydrogenase (quinone)

Reaction: (S)-malate + a quinone = oxaloacetate + reduced quinone

Other name(s): FAD-dependent malate-vitamin K reductase; malate-vitamin K reductase; (S)-malate:(acceptor) oxidoreductase; L-malate-quinone oxidoreductase; malate:quinone oxidoreductase; malate quinone oxidoreductase; MQO; malate:quinone reductase; malate dehydrogenase (acceptor); FAD-dependent malate dehydrogenase

Systematic name: (S)-malate:quinone oxidoreductase

Comments: A flavoprotein (FAD). Vitamin K and several other quinones can act as acceptors. Different from EC [malate dehydrogenase (NAD+)], EC [malate dehydrogenase (NADP+)] and EC [malate dehydrogenase [NAD(P)+)].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Imai, D. and Brodie, A.F. A phospholipid-requiring enzyme, malate-vitamin K reductase. J. Biol. Chem. 248 (1973) 7487-7494.

2. Imai, T. FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties. Biochim. Biophys. Acta 523 (1978) 37-46. [PMID: 629992]

3. Reddy, T.L.P., Suryanarayana, P.M. and Venkitasubramanian, T.A. Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria. Biochim. Biophys. Acta 376 (1975) 210-218. [PMID: 234747]

4. Molenaar, D., van der Rest, M.E. and Petrovic, S. Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum. Eur. J. Biochem. 254 (1998) 395-403. [PMID: 9660197]

5. Kather, B., Stingl, K., van der Rest, M.E., Altendorf, K. and Molenaar, D. Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase. J. Bacteriol. 182 (2000) 3204-3209. [PMID: 10809701]

[EC created 1978 as EC, transferred 2009 to EC]

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