IUBMB Enzyme Nomenclature


Accepted name: glutathione peroxidase

Reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

Other name(s): GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase

Systematic name: glutathione:hydrogen-peroxide oxidoreductase

Comments: A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC phospholipid-hydroperoxide glutathione peroxidase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9013-66-5


1. Chaudiere, J. and Tappel, A.L. Purification and characterization of selenium-glutathione peroxidase from hamster liver. Arch. Biochem. Biophys. 226 (1983) 448-457. [PMID: 6227287]

2. Grossmann, A. and Wendel, A. Non-reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids. Eur. J. Biochem. 135 (1983) 549-552. [PMID: 6413205]

3. Nakamura, W., Hosoda, S. and Hayashi, K. Purification and properties of rat liver glutathione peroxidase. Biochim. Biophys. Acta 358 (1974) 251-261.

[EC created 1965, modified 1989]

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