Reaction: indole + O2 = 2-formylaminobenzaldehyde
Other name(s): indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase ; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous)
Systematic name: indole:oxygen 2,3-oxidoreductase (decyclizing)
Comments: The enzyme from the plant Jasminum grandiflorum is a flavoprotein containing copper, and forms anthranilate as the final product. One enzyme from Tecoma stans is also a flavoprotein containing copper and uses three atoms of oxygen per molecule of indole, to form anthranil (3,4-benzoisoxazol). A second enzyme from Tecoma stans, which is not a flavoprotein, uses four atoms of oxygen and forms anthranilate as the final product.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 37256-57-8
References:
1. Divakar, N.G., Subramanian, V., Sugumaran, M. and Vaidyanathan, C.S. Indole oxygenase from the leaves of Jasminum grandiflorum. Plant Sci. Lett. 15 (1979) 177-181.
2. Kunapuli, S.P. and Vaidyanathan, C.S. Purification and characterization of a new indole oxygenase from the leaves of Tecoma stans L. Plant Physiol. 71 (1983) 19-23.
3. Nair, P.M. and Vaidyanathan, C.S. An indole oxidase isolated from the leaves of Tecoma stans. Biochim. Biophys. Acta 81 (1964) 496-506.