IUBMB Enzyme Nomenclature


Accepted name: chloridazon-catechol dioxygenase

Reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone

Other name(s): 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)

Systematic name: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (ring-opening)

Comments: An iron protein, requiring additional Fe2+. Not identical with EC (catechol 1,2-dioxygenase), EC (catechol 2,3-dioxygenase) or EC (homogentisate 1,2-dioxygenase). Involved in the breakdown of the herbicide chloridazon.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 82869-32-7


1. Müller, R, Haug, S., Eberspächer, J. and Lingens, F. Catechol-2,3-Dioxygenase aus Pyrazon-abbauenden Bakterien. Hoppe-Seyler's Z. Physiol. Chem. 358 (1977) 797-805. [PMID: 19349]

2. Müller, R., Schmitt, S. and Lingens, F. A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986. Eur. J. Biochem. 125 (1982) 579-584. [PMID: 6811270]

[EC created 1984]

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