Reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate
Other name(s): hydroxyquinol dioxygenase
Systematic name: benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)
Comments: An iron protein. The product isomerizes to 2-maleylacetate (cis-hexenedioate). Highly specific; catechol and pyrogallol are acted on at less than 1% of the rate at which hydroxyquinol is oxidized.
Links to other databases: BRENDA, EXPASY, KEGG, UM-BBD, CAS registry number: 91847-14-2
References:
1. Sze, I.S.-Y. and Dagley, S. Properties of salicylate hydroxylase and hydroxyquinol 1,2-dioxygenase purified from Trichosporon cutaneum. J. Bacteriol. 159 (1984) 353-359. [PMID: 6539772]