IUBMB Enzyme Nomenclature

EC 1.13.11.50

Reaction: pentane-2,4-dione + O2 = acetate + methylglyoxal

Glossary: methylglyoxal = 2-oxopropanal

Other name(s): Dke1; acetylacetone dioxygenase; diketone cleaving dioxygenase; diketone cleaving enzyme

Systematic name: acetylacetone:oxygen oxidoreductase

Comments: An Fe(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 524047-53-8

References:

1. Straganz, G.D., Glieder, A., Brecker, L., Ribbons, D.W. and Steiner, W. Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii. Biochem. J. 369 (2003) 573-581. [PMID: 12379146]

[EC 1.13.11.50 created 2003]


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