IUBMB Enzyme Nomenclature

EC 1.13.12.4

Accepted name: lactate 2-monooxygenase

Reaction: (S)-lactate + O2 = acetate + CO2 + H2O

Other name(s): lactate oxidative decarboxylase; lactate oxidase; lactic oxygenase; lactate oxygenase; lactic oxidase; L-lactate monooxygenase; lactate monooxygenase; L-lactate-2-monooxygenase

Systematic name: (S)-lactate:oxygen 2-oxidoreductase (decarboxylating)

Comments: A flavoprotein (FMN). Formerly EC 1.1.3.2.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-72-2

References:

1. Hayaishi, O. and Sutton, W.B. Enzymatic oxygen fixation into acetate concomitant with the enzymatic decarboxylation of L-lactate. J. Am. Chem. Soc. 79 (1957) 4809-4810..

2. Sutton, W.B. Mechanism of action and crystalization of lactic oxidative decarboxylase from Mycobacterium phlei. J. Biol. Chem. 226 (1957) 395-405.

[EC 1.13.12.4 created 1961 as EC 1.1.3.2, transferred 1972 to EC 1.13.12.4]


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