Reaction: peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2
Other name(s): aspartate β-hydroxylase; aspartylpeptide β-dioxygenase
Systematic name: peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Comments: Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 122544-66-5
1. Gronke, R.S., Welsch, D.J., VanDusen, W.J., Garsky, V.M., Sardana, M.K., Stern, A.M. and Friedman, P.A. Partial purification and characterization of bovine liver aspartyl β-hydroxylase. J. Biol. Chem. 265 (1990) 8558-8565. [PMID: 2187868]