IUBMB Enzyme Nomenclature

EC 1.14.11.19

Accepted name: leucocyanidin oxygenase

Reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- and trans-dihydroquercetins + succinate + CO2 + 2 H2O

For diagram, click here

Other name(s): anthocyanidin synthase

Systematic name: leucocyanidin,2-oxoglutarate:oxygen oxidoreductase

Comments: The enzyme requires Fe(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin (glycosylated anthocyandin) flower pigments. The intermediates are transformed into cis- and trans-dihydroquercetin [2], which the enzyme can also oxidize to quercetin. Acidification of the products gives anthocyanidin [1], which, however, may not be a natural precursor of the anthocyanins.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 180984-01-4

References:

1. Saito, K., Kobayashi, M., Gong, Z., Tanaka, Y. and Yamazaki, M. Direct evidence for anthocyanidin synthase as a 2-oxoglutarate-dependent oxygenase: molecular cloning and functional expression of cDNA from a red forma of Perilla frutescens. Plant J. 17 (1999) 181-190. [PMID: 10074715]

2. Turnbull, J.J., Sobey, W.J., Aplin, R.T., Hassan, A., Firmin, J.L., Schofield, C.J. and Prescott, A.G. Are anthocyanidins the immediate products of anthocyanidin synthase? Chem. Commun. (2000) 2473-2474.

[EC 1.14.11.19 created 2001]


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