IUBMB Enzyme Nomenclature


Accepted name: flavone synthase

Reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O

See diagram for reaction in apigenin or luteolin biosynthesis.

Other Name(s): flavone synthase I; FNS I

Systematic name: flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating)

Comments: Requires ascorbate for full activity and Fe2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 138263-98-6

References: (if your browser cannot recognise unicode the author is Lukacin with a hacek over the c)

1. Martens, S., Forkmann, G., Matern, U. and Lukačin, R. Cloning of parsley flavone synthase I. Phytochemistry 58 (2001) 43-46. [PMID: 11524111]

2. Lukačin, R., Matern, U., Junghanns, K.T., Heskamp, M.L., Britsch, L., Forkmann, G. and Martens, S. Purification and antigenicity of flavone synthase I from irradiated parsley cells. Arch. Biochem. Biophys. 393 (2001) 177-183. [PMID: 11516175]

3. Martens, S., Forkmann, G., Britsch, L., Wellmann, F., Matern, U. and Lukačin, R. Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley. FEBS Lett. 544 (2003) 93-98. [PMID: 12782296]

[EC created 2004]

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