IUBMB Enzyme Nomenclature


Accepted name: flavanone 3-dioxygenase

Reaction: a flavanone + 2-oxoglutarate + O2 = a dihydroflavonol + succinate + CO2

See diagram for reaction in aromadendrin or taxifolin biosynthesis.

Other name(s): naringenin 3-hydroxylase; flavanone 3-hydroxylase; flavanone 3β-hydroxylase; flavanone synthase I; (2S)-flavanone 3-hydroxylase; naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Systematic name: flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Comments: Requires Fe2+ and ascorbate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 75991-43-4

References: (if your browser cannot recognise unicode the author is Lukacin with a hacek over the c)

1. Forkmann, G., Heller, W. and Grisebach, H. Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases. Z. Naturforsch. C: Biosci. 35 (1980) 691-695.

2. Wellmann, F., Matern, U. and Lukačin, R. Significance of C-terminal sequence elements for Petunia flavanone 3β-hydroxylase activity. FEBS Lett. 561 (2004) 149-154. [PMID: 15013767]

[EC created 1983, modified 1989, modified 2004]

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