IUBMB Enzyme Nomenclature

EC 1.14.12.17

Accepted name: nitric oxide dioxygenase

Reaction: 2 nitric oxide + 2 O2 + NAD(P)H = 2 nitrate + NAD(P)+ + H+

Glossary: nitric oxide = NO

Systematic name: nitric oxide,NAD(P)H:oxygen oxidoreductase

Comments: A flavohemoglobin (FAD). It has been proposed that FAD functions as the electron carrier from NADPH to the ferric heme prosthetic group.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 214466-78-1

References:

1. Gardner, P.R., Costantino, G. and Salzman, A.L. Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase. J. Biol. Chem. 273 (1998) 26528-26533. [PMID: 9756889]

2. Gardner, P.R., Gardner, A.M., Martin, L.A. and Salzman, A.L. Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proc. Natl. Acad. Sci. USA 95 (1998) 10378-10383. [PMID: 9724711]

[EC 1.14.12.17 created 2000]


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