IUBMB Enzyme Nomenclature


Accepted name: 5-epiaristolochene 1,3-dihydroxylase

Reaction: 5-epiaristolochene + 2 NADPH + 2 H+ + 2 O2 = capsidiol + 2 NADP+ + 2 H2O

For diagram of reaction click here.

Other name(s): 5-epi-aristolochene 1,3-dihydroxylase; EAH

Systematic name: 5-epiaristolochene,NADPH:oxygen oxidoreductase (1- and 3-hydroxylating)

Comments: A heme-thiolate protein (P-450). Kinetic studies suggest that 1β-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3. However the reverse order via 3α-hydroxyepiaristolochene does occur.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Ralston, L., Kwon, S.T., Schoenbeck, M., Ralston, J., Schenk, D.J., Coates, R.M. and Chappell, J. Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1,3-dihydroxylase from tobacco (Nicotiana tabacum). Arch. Biochem. Biophys. 393 (2001) 222-235. [PMID: 11556809]

2. Takahashi, S., Zhao, Y., O'Maille, P.E., Greenhagen, B.T., Noel, J.P., Coates, R.M. and Chappell, J. Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. J. Biol. Chem. 280 (2005) 3686-3696. [PMID: 15522862]

[EC created 2011]

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