IUBMB Enzyme Nomenclature

EC 1.14.13.17

Accepted name: cholesterol 7α-monooxygenase

Reaction: cholesterol + NADPH + H+ + O2 = 7α-hydroxycholesterol + NADP+ + H2O

For diagram click here.

Other name(s): cholesterol 7α-hydroxylase; CYP7A1

Systematic name: cholesterol,NADPH:oxygen oxidoreductase (7α-hydroxylating)

Comments: A heme-thiolate protein (P-450).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9037-53-0

References:

1. Boyd, G.S., Grimwade, A.M. and Lawson, M.E. Studies on rat-liver microsomal cholesterol 7α-hydroxylase. Eur. J. Biochem. 37 (1973) 334-340. [PMID: 4147676]

2. Mitton, J.R., Scholan, N.A. and Boyd, G.S. The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7α-hydroxylase enzyme system. Eur. J. Biochem. 20 (1971) 569-579. [PMID: 4397276]

3. Ogishima, T., Deguchi, S. and Okuda, K. Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes. J. Biol. Chem. 262 (1987) 7646-7650. [PMID: 3584134]

[EC 1.14.13.17 created 1976]


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