Reaction: anhydrotetracycline + NADPH + H+ + O2 = 12-dehydrotetracycline + NADP+ + H2O
Other name(s): ATC oxygenase; anhydrotetracycline oxygenase
Systematic name: anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)
Comments: Involved in the biosynthesis of the antibiotics tetracyclines in Streptomyces sp.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 70766-62-0
References:
1. Behal, V. The tetracycline fermentation and its regulation. CRC Crit. Rev. Biotechnol. 5 (1987) 295-318.