IUBMB Enzyme Nomenclature


Accepted name: (S)-limonene 6-monooxygenase

Reaction: (S)-limonene + NADPH + H+ + O2 = (–)-trans-carveol + NADP+ + H2O

For diagram click here.

limonene: a monoterpenoid
(S)-limonene = (–)-limonene

Other name(s): (–)-limonene 6-hydroxylase; (–)-limonene 6-monooxygenase; (–)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)

Systematic name: (S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)

Comments: High specificity, but NADH can act instead of NADPH, but more slowly. A heme-thiolate protein (P-450).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 138066-93-0


1. Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R. Monoterpene biosynthesis: specificity of the hydroxylations of (–)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276 (1990) 219-226. [PMID: 90120595]

[EC created 1992, modified 2003]

Return to EC 1.14.13 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page