Reaction: (S)-limonene + NADPH + H+ + O2 = (–)-perillyl alcohol + NADP+ + H2O
For diagram click here.
Glossary:
limonene: a monoterpenoid
(S)-limonene = (–)-limonene
Other name(s): (–)-limonene 7-monooxygenase; (–)-limonene hydroxylase; (–)-limonene monooxygenase; (–)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)
Systematic name: (S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)
Comments: High specificity, but NADH can act instead of NADPH, although more slowly. A heme-thiolate protein (P-450).
Links to other databases: BRENDA, EXPASY, KEGG, UM-BBD, CAS registry number: 122653-75-2
References:
1. Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R. Monoterpene biosynthesis: specificity of the hydroxylations of (–)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276 (1990) 219-226. [PMID: 2297225]