Reaction: protopine + NADPH + H+ + O2 = 6-hydroxyprotopine + NADP+ + H2O
For diagram click here.
Other name(s): protopine 6-hydroxylase
Systematic name: protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)
Comments: a heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 128561-60-4
1. Tanahashi, T. and Zenk, M.H. Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis. Phytochemistry 29 (1990) 1113-1122.