IUBMB Enzyme Nomenclature

EC 1.14.13.7

Accepted name: phenol 2-monooxygenase (NADPH)

Reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O

Glossary: o-cresol = 2-cresol = 2-methylphenol

Other name(s): phenol hydroxylase; phenol o-hydroxylase

Systematic name: phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)

Comments: A flavoprotein (FAD). The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyse the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. cf. EC 1.14.14.20, phenol 2-monooxygenase (FADH2).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 37256-84-1

References:

1. Nakagawa, H. and Takeda, Y. Phenol hydroxylase. Biochim. Biophys. Acta 62 (1962) 423-426. [PMID: 14478080]

2. Neujahr, H.Y. and Gaal, A. Phenol hydroxylase from yeast. Purification and properties of the enzyme from Trichosporon cutaneum, Eur. J. Biochem. 35 (1973) 386-400. [PMID: 4146224]

3. Neujahr, H.Y. and Gaal, A. Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum, Eur. J. Biochem. 58 (1975) 351-357. [PMID: 810352]

[EC 1.14.13.7 created 1972, modified 2011, modified 2016]


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