Reaction: (S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3'-hydroxy-N-methylcoclaurine + NADP+ + H2O
For diagram click here.
Other name(s): N-methylcoclaurine 3'-hydroxylase
Systematic name: (S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)
Comments: A heme-thiolate protein (P-450) involved in benzylisoquinoline alkaloid synthesis in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 202420-37-9
1. Pauli, H.H. and Kutchan, T.M. Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. Plant. J. 13 (1998) 793-801. [PMID: 9681018]