IUBMB Enzyme Nomenclature


Accepted name: licodione synthase

Reaction: liquiritigenin + NADPH + H+ + O2 = licodione + NADP+ + H2O

For diagram click here.

Glossary: licodione = 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)propane-1,3-dione

Systematic name: liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming)

Comments: A heme-thiolate protein (P-450). It probably forms 2-hydroxyliquiritigenin which spontaneously forms licodione. NADH can act instead of NADPH, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 157972-05-9


1. Otani, K., Takahashi, T., Furuya, T. and Ayabe, S. Licodione synthase, a cytochrome P450 monooxygenase catalyzing 2-hydroxylation of 5-deoxyflavanone, in cultured Glycyrrhiza echinata L. cells. Plant Physiol. 105 (1994) 1427-1432. [PMID: 12232298]

2. Akashi, T., Aoki, T. and Ayabe, S. Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II. FEBS Lett. 431 (1998) 287-290. [PMID: 9708921]

[EC created 2004]

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